Unweaving type I interferons in age-related neuroinflammation

David P J Hunt; Markus J Hofer

doi:10.1016/j.tins.2024.08.014

Unweaving type I interferons in age-related neuroinflammation

Trends Neurosci. 2024 Oct;47(10):751-752. doi: 10.1016/j.tins.2024.08.014. Epub 2024 Sep 4.

Authors

David P J Hunt¹, Markus J Hofer²

Affiliations

¹ UK Dementia Research Institute at University of Edinburgh, Edinburgh, EH16 4SB, UK; Centre for Clinical Brain Sciences at University of Edinburgh, Edinburgh, EH16 4SB, UK.
² School of Life and Environmental Sciences and the Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: [email protected].

PMID: 39237428
DOI: 10.1016/j.tins.2024.08.014

Abstract

Neuroinflammation is a feature of both neurodegenerative disease and normal brain aging. The roles of type I interferon (IFN-I) in the aged brain are incompletely understood. A recent article by Roy et al. reveals pervasive IFN-I activity in normal mouse brain aging, and highlights the importance of microglial IFN-I signaling in neuroinflammation.

Keywords: RNA sequencing; brain aging; dementia; mouse model; neurodegeneration; neuroimmune.

MeSH terms

Aging* / immunology
Animals
Brain / immunology
Brain / metabolism
Interferon Type I* / immunology
Interferon Type I* / metabolism
Mice
Microglia / immunology
Microglia / metabolism
Neuroinflammatory Diseases* / immunology
Neuroinflammatory Diseases* / metabolism
Signal Transduction / physiology

Substances

Interferon Type I