Relationship between Urine Serotonin and Persistent Pulmonary Hypertension of the Newborn

Jamie L Archambault; Teri L Hernandez; Eva S Nozik; Claire Palmer; Mairead Dillon; Ravinder J Singh; Csaba Galambos; Cassidy A Delaney

doi:10.1016/j.jpeds.2024.114290

Relationship between Urine Serotonin and Persistent Pulmonary Hypertension of the Newborn

J Pediatr. 2025 Jan:276:114290. doi: 10.1016/j.jpeds.2024.114290. Epub 2024 Sep 4.

Authors

Jamie L Archambault¹, Teri L Hernandez², Eva S Nozik³, Claire Palmer¹, Mairead Dillon¹, Ravinder J Singh⁴, Csaba Galambos⁵, Cassidy A Delaney⁶

Affiliations

¹ Section of Neonatology, Department of Pediatrics, University of Colorado, Aurora, CO.
² College of Nursing, University of Colorado, Aurora, CO; Section of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado, Aurora, CO.
³ Section of Pediatric Critical Care, Department of Pediatrics, University of Colorado, Aurora, CO.
⁴ Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN.
⁵ Section of Pathology, Department of Pediatrics, University of Colorado, Aurora, CO.
⁶ Section of Neonatology, Department of Pediatrics, University of Colorado, Aurora, CO. Electronic address: [email protected].

PMID: 39242076
DOI: 10.1016/j.jpeds.2024.114290

Abstract

Urine serotonin (5-HT)/creatinine was lower at day of life 3 in newborns with pulmonary hypertension compared with controls, while the percent change in the 5-HT metabolite, 5-hydroxyindoleacetic acid (5-HIAA)/creatinine increased. We speculate that the changes in 5-HT and 5-HIAA reflect enhanced pulmonary 5-HT uptake and/or metabolism.

Keywords: neonate; pulmonary hypertension; serotonin.

MeSH terms

Biomarkers / urine
Case-Control Studies
Creatinine / urine
Female
Humans
Hydroxyindoleacetic Acid* / urine
Hypertension, Pulmonary / urine
Infant, Newborn
Male
Serotonin* / urine

Substances

Serotonin
Hydroxyindoleacetic Acid
Creatinine
Biomarkers