Telomere dynamics as mediators of gut microbiota-host interactions

Michael L Pepke; Søren B Hansen; Morten T Limborg

doi:10.1016/j.tcb.2024.08.003

Telomere dynamics as mediators of gut microbiota-host interactions

Trends Cell Biol. 2024 Oct;34(10):805-808. doi: 10.1016/j.tcb.2024.08.003. Epub 2024 Sep 9.

Authors

Michael L Pepke¹, Søren B Hansen², Morten T Limborg²

Affiliations

¹ Center for Evolutionary Hologenomics, Globe Institute, Faculty of Health and Medical Sciences, Øster Farimagsgade 5, DK-1353 Copenhagen, University of Copenhagen, Denmark. Electronic address: [email protected].
² Center for Evolutionary Hologenomics, Globe Institute, Faculty of Health and Medical Sciences, Øster Farimagsgade 5, DK-1353 Copenhagen, University of Copenhagen, Denmark.

PMID: 39256139
DOI: 10.1016/j.tcb.2024.08.003

Abstract

The highly proliferative gut tissue exhibits rapid telomere shortening with systemic effects on the host organism. Recent studies have demonstrated a bidirectionality in interactions between intestinal telomere length dynamics and the composition and activity of the gut microbiome thus linking processes of inflammation, dysbiosis and aging across different vertebrate species.

Keywords: gut barrier; holobiont; microbiome; senescence; telomerase; telomere length.

MeSH terms

Aging / metabolism
Animals
Gastrointestinal Microbiome*
Humans
Telomere* / metabolism