The power of many: Multilevel targeting of representative chemokine and metabolite GPCRs in personalized cancer therapy

Eur J Immunol. 2024 Dec;54(12):e2350870. doi: 10.1002/eji.202350870. Epub 2024 Sep 12.

Abstract

G protein-coupled receptors (GPCRs) are vital cell surface receptors that govern a myriad of physiological functions. Despite their crucial role in regulating antitumor immunity and tumorigenesis, therapeutic applications targeting GPCRs in oncology are currently limited. This review offers a focused examination of selected protumorigenic chemokine and metabolite-sensing GPCRs. Specifically, the review highlights five GPCRs able to orchestrate tumor immunobiology at three main levels: tumor immunity, cancer cell expansion, and blood vessel development. The review culminates by illuminating emerging therapies and discussing innovative strategies to harness the full potential of GPCR-targeted treatments, by applying a multireceptor and patient-specific logic.

Keywords: Angiogenesis; Cancer; GPCRs; Immunity; Treatment.

Publication types

  • Review

MeSH terms

  • Animals
  • Chemokines* / immunology
  • Chemokines* / metabolism
  • Humans
  • Molecular Targeted Therapy
  • Neoplasms* / drug therapy
  • Neoplasms* / immunology
  • Neoplasms* / metabolism
  • Neoplasms* / therapy
  • Precision Medicine* / methods
  • Receptors, G-Protein-Coupled* / immunology
  • Receptors, G-Protein-Coupled* / metabolism
  • Signal Transduction

Substances

  • Receptors, G-Protein-Coupled
  • Chemokines