Remember oligodendrocytes: Uncovering their overlooked role in Alzheimer's disease

PLoS Biol. 2024 Sep 12;22(9):e3002798. doi: 10.1371/journal.pbio.3002798. eCollection 2024 Sep.

Abstract

Our understanding of Alzheimer's disease (AD) has evolved from focusing solely on neurons to recognizing the role of glia. A recent study in PLOS Biology revealed that oligodendrocytes are an important source of Aβ that impairs neuronal function.

Publication types

  • Comment

MeSH terms

  • Alzheimer Disease* / metabolism
  • Alzheimer Disease* / pathology
  • Amyloid beta-Peptides* / metabolism
  • Animals
  • Humans
  • Neurons / metabolism
  • Neurons / physiology
  • Oligodendroglia* / metabolism
  • Oligodendroglia* / pathology
  • Oligodendroglia* / physiology

Substances

  • Amyloid beta-Peptides

Grants and funding

The authors received no specific funding for this work.