There and back again: Discovering antiviral and antiphage defenses using deep homology

Edward M Culbertson; Tera C Levin

doi:10.1016/j.chom.2024.08.006

There and back again: Discovering antiviral and antiphage defenses using deep homology

Cell Host Microbe. 2024 Sep 11;32(9):1466-1468. doi: 10.1016/j.chom.2024.08.006.

Authors

Edward M Culbertson¹, Tera C Levin²

Affiliations

¹ University of Pittsburgh, Department of Biological Sciences, Pittsburgh, PA, USA.
² University of Pittsburgh, Department of Biological Sciences, Pittsburgh, PA, USA. Electronic address: [email protected].

PMID: 39265534
DOI: 10.1016/j.chom.2024.08.006

Abstract

Two recent studies in Cell Host & Microbe (Cury et al. and van den Berg et al.) uncover cross-kingdom links between antiphage and antiviral immune defenses. Through reciprocal computational and wet lab approaches, they each discover and experimentally validate proteins used for host immunity.

MeSH terms

Antiviral Agents / immunology
Bacteriophages / immunology
Bacteriophages / physiology
Computational Biology / methods
Host-Pathogen Interactions* / immunology
Humans

Substances

Antiviral Agents