Abstract
Inflammatory bowel disease (IBD) is a chronic non-specific intestinal inflammatory disease that affects millions of people worldwide, and current treatment methods have certain limitations. This study aimed to explore the therapeutic potential and mechanism of action of lemairamin (Wgx-50) in inflammatory bowel disease (IBD). We used dextran sulfate sodium (DSS)-treated zebrafish as an inflammatory bowel disease model, and observed the effect of Wgx-50 on DSS-induced colitis inflammation. The results of the study showed that Wgx-50 could reduce the expression of pro-inflammatory cytokines induced by DSS and inhibit the recruitment of neutrophils to the site of intestinal injury. Further experiments revealed that Wgx-50 exerted its anti-inflammatory effect by regulating the activation of the Akt pathway. These research findings indicate that Wgx-50 possesses anti-inflammatory activity.
Keywords:
DSS; IBD; Wgx-50; neutrophils; zebrafish.
MeSH terms
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Animals
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Anti-Inflammatory Agents* / pharmacology
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Colitis* / chemically induced
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Colitis* / drug therapy
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Colitis* / metabolism
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Colitis* / pathology
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Cytokines / metabolism
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Dextran Sulfate* / adverse effects
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Disease Models, Animal*
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Inflammation / chemically induced
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Inflammation / drug therapy
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Inflammation / metabolism
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Inflammation / pathology
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Inflammatory Bowel Diseases / chemically induced
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Inflammatory Bowel Diseases / drug therapy
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Inflammatory Bowel Diseases / metabolism
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Inflammatory Bowel Diseases / pathology
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Intestines / drug effects
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Intestines / pathology
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Neutrophils / drug effects
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Neutrophils / metabolism
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Proto-Oncogene Proteins c-akt / metabolism
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Signal Transduction / drug effects
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Zebrafish*
Substances
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Dextran Sulfate
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Anti-Inflammatory Agents
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Cytokines
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Proto-Oncogene Proteins c-akt
Grants and funding
This work was supported by the National Natural Science Foundation of China (31972531), National Key Research and Development Program of China (2021YFD1301200), Anhui Provincial Natural Science Foundation (2208085Y10), Major Special Science and Technology Project of Anhui Province (202103b06020023), Open Project of Provincial and Ministerial Scientific Research Platform, Fuyang Normal University (FSKFKT008).