Development of the Pancreatic Ducts and Their Contribution to Organogenesis

Dorian J Dale; Caleb D Rutan; Teresa L Mastracci

doi:10.1007/978-3-031-62232-8_2

Development of the Pancreatic Ducts and Their Contribution to Organogenesis

Adv Anat Embryol Cell Biol. 2024:239:31-55. doi: 10.1007/978-3-031-62232-8_2.

Authors

Dorian J Dale¹, Caleb D Rutan¹, Teresa L Mastracci^{2

3

4}

Affiliations

¹ Department of Biology, Indiana University-Indianapolis, Indianapolis, IN, USA.
² Department of Biology, Indiana University-Indianapolis, Indianapolis, IN, USA. [email protected].
³ Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA. [email protected].
⁴ Center for Diabetes and Metabolic Disease, Indiana University School of Medicine, Indianapolis, IN, USA. [email protected].

PMID: 39283481
DOI: 10.1007/978-3-031-62232-8_2

Abstract

The pancreas is a dual-function organ, with exocrine cells that aid in digestion and endocrine cells that regulate glucose homeostasis. These cell types share common progenitors and arise from the embryonic ducts. Early signaling events in the embryonic ducts shape the neonatal, adolescent, and adult exocrine and endocrine pancreas. This chapter discusses recent advances in the tools used to study the ducts and our current understanding of how ductal development contributes to pancreatic organogenesis.

Keywords: Acinar; Duct; Pancreas; Progenitor.

Publication types

Review

MeSH terms

Animals
Humans
Organogenesis*
Pancreas / embryology
Pancreas / growth & development
Pancreatic Ducts* / cytology
Pancreatic Ducts* / embryology
Signal Transduction