Subcutaneous adipose tissue and skeletal muscle mitochondria following weight loss

Birgitta W van der Kolk; Eija Pirinen; Rachel Nicoll; Kirsi H Pietiläinen; Sini Heinonen

doi:10.1016/j.tem.2024.08.002

Subcutaneous adipose tissue and skeletal muscle mitochondria following weight loss

Trends Endocrinol Metab. 2024 Sep 16:S1043-2760(24)00221-2. doi: 10.1016/j.tem.2024.08.002. Online ahead of print.

Authors

Birgitta W van der Kolk¹, Eija Pirinen², Rachel Nicoll³, Kirsi H Pietiläinen⁴, Sini Heinonen⁵

Affiliations

¹ Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland. Electronic address: [email protected].
² Research Program for Clinical and Molecular Metabolism, University of Helsinki, Finland; Faculty of Medicine, Research Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland.
³ Research Program for Clinical and Molecular Metabolism, University of Helsinki, Finland.
⁴ Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; HealthyWeightHub, Endocrinology, Abdominal Center, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
⁵ Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Department of Internal Medicine, Helsinki University Hospital, Helsinki, Finland. Electronic address: [email protected].

PMID: 39289110
DOI: 10.1016/j.tem.2024.08.002

Abstract

Obesity is a major global health issue with various metabolic complications. Both bariatric surgery and dieting achieve weight loss and improve whole-body metabolism, but vary in their ability to maintain these improvements over time. Adipose tissue and skeletal muscle metabolism are crucial in weight regulation, and obesity is linked to mitochondrial dysfunction in both tissues. The impact of bariatric surgery versus dieting on adipose tissue and skeletal muscle mitochondrial metabolism remains to be elucidated. Understanding the molecular pathways that modulate tissue metabolism following weight loss holds potential for identifying novel therapeutic targets in obesity management. This narrative review summarizes current knowledge on mitochondrial metabolism following bariatric surgery and diet-induced weight loss in adipose tissue and skeletal muscle, and sheds light on their respective effects.

Keywords: adipose tissue; bariatric surgery; caloric restriction; mitochondria; obesity; skeletal muscle.

Publication types

Review