Neonatal reference values and nomograms of systemic vascular resistances estimated with electrical cardiometry

Valeria Bisceglie; Barbara Loi; Ottavio Vitelli; Alice Proto; Maria Elena Ferrari; Laura Vivalda; Matteo Di Nardo; Stefano Martinelli; Daniele De Luca

doi:10.1038/s41372-024-02115-x

Neonatal reference values and nomograms of systemic vascular resistances estimated with electrical cardiometry

J Perinatol. 2024 Sep 17. doi: 10.1038/s41372-024-02115-x. Online ahead of print.

Authors

Affiliations

¹ Division of Pediatrics and Neonatal Critical Care, "A. Béclère" Medical Center, Paris-Saclay University Hospitals, APHP, Paris, France.
² Physiopathology and Therapeutic Innovation Unit-INSERM U999, Paris-Saclay University, Paris, France.
³ Division of Neonatology and Neonatal Intensive Care Unit, ASST Grande Ospedale Metropolitano "Niguarda", Milan, Italy.
⁴ Pediatric Intensive Care Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
⁵ Division of Pediatrics and Neonatal Critical Care, "A. Béclère" Medical Center, Paris-Saclay University Hospitals, APHP, Paris, France. [email protected].
⁶ Physiopathology and Therapeutic Innovation Unit-INSERM U999, Paris-Saclay University, Paris, France. [email protected].

PMID: 39289555
DOI: 10.1038/s41372-024-02115-x

Abstract

Objective: Scanty data are available about neonatal systemic vascular resistances (SVR). We aim to provide reference values and nomograms for neonatal SVR.

Design: Multicenter, cross-sectional,descriptive study performed in France and Italy. Neonates with complete hemodynamic stability were enrolled. Non-invasive measurements of SVR by electrical cardiometry performed once, after the first 72 h and before the 7th day of postnatal age.

Results: We studied 1094 neonates: SVR was correlated with gestational age (ρ = -0.55, adj-r = -0.46, p < 0.001) and birth weight (ρ = -0.59, adj-r = -0.45, p < 0.001) irrespective of newborn sex. The relationships between SVR, gestational age and birth weight were represented by power equations and SVR was decreasing with increasing age and weight. Age- and weight-based SVR nomograms had optimal goodness-of-fit (non-linear R² ≥0.74). Similar results were obtained for body surface indexed-SVR.

Conclusions: In hemodynamically stable neonates, SVR decrease with increasing gestational age and birth weight. Specific gestational age and birth weight-based nomograms are provided for the clinical interpretation.