Torsemide in the Management of Essential Hypertension

J Assoc Physicians India. 2024 Sep;72(9S):35-37. doi: 10.59556/japi.72.0676.

Abstract

Torsemide, a loop diuretic, is increasingly recognized for its role in managing essential hypertension. Its mechanism of action involves inhibiting the reabsorption of sodium and chloride ions in the ascending loop of Henle in the kidneys. By doing so, torsemide promotes diuresis, which refers to increased urine production, and subsequently lowers blood pressure. Studies have shown that torsemide is comparably effective to other antihypertensive agents in lowering blood pressure, with the added benefit of potentially improving renal function. However, while torsemide shows promise in hypertensive management, further research is necessary to fully understand its long-term effects and to establish optimal dosing strategies. Future research should focus on clarifying its role in long-term blood pressure control and refining its use in clinical practice to maximize efficacy and minimize adverse effects.

Publication types

  • Review

MeSH terms

  • Antihypertensive Agents* / pharmacology
  • Antihypertensive Agents* / therapeutic use
  • Blood Pressure / drug effects
  • Essential Hypertension* / drug therapy
  • Humans
  • Hypertension* / drug therapy
  • Sodium Potassium Chloride Symporter Inhibitors* / pharmacology
  • Sodium Potassium Chloride Symporter Inhibitors* / therapeutic use
  • Torsemide* / pharmacology
  • Torsemide* / therapeutic use

Substances

  • Antihypertensive Agents
  • Torsemide
  • Sodium Potassium Chloride Symporter Inhibitors