Isochronous islands in phase space emerge in twist Hamiltonian systems as a response to multiple resonant perturbations. According to the Poincaré-Birkhoff theorem, the number of islands depends on the system characteristics and the perturbation. We analyze, for the two-parameter standard map, also called two-harmonic standard map, how the island chains are modified as the perturbation amplitude increases. We identified three routes for the transition from one chain, associated with one harmonic, to the chain associated with the other harmonic, based on a combination of pitchfork and saddle-node bifurcations. These routes can present intermediate island chains configurations. Otherwise, the destruction of the islands always occurs through the pitchfork bifurcation.