Multiple applications of metal-organic frameworks (MOFs) in the treatment of orthopedic diseases

Ziwen Zhao; Chenxu Wang; Aiguo Liu; Ning Bai; Bo Jiang; Yuanfu Mao; Ting Ying; Daming Dong; Chengqing Yi; Dejian Li

doi:10.3389/fbioe.2024.1448010

Multiple applications of metal-organic frameworks (MOFs) in the treatment of orthopedic diseases

Front Bioeng Biotechnol. 2024 Sep 4:12:1448010. doi: 10.3389/fbioe.2024.1448010. eCollection 2024.

Authors

Ziwen Zhao^#^{1

2}, Chenxu Wang^#³, Aiguo Liu^#³, Ning Bai⁴, Bo Jiang⁵, Yuanfu Mao¹, Ting Ying⁶, Daming Dong¹, Chengqing Yi², Dejian Li²

Affiliations

¹ Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
² Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.
³ Department of Orthopedics, The First Affiliated Hospital of Henan University, Kaifeng, China.
⁴ Department of Gastroenterology, Huaihe Hospital of Henan University, Kaifeng, China.
⁵ The First Affiliated Hospital of Ningbo University, Ningbo, China.
⁶ Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

^# Contributed equally.

Abstract

Pharmacologic treatment of orthopedic diseases is a common challenge for clinical orthopedic surgeons, and as an important step in the stepwise treatment of orthopedic diseases, it is often difficult to achieve satisfactory results with existing pharmacologic treatments. Therefore, it is increasingly important to find new ways to effectively improve the treatment pattern of orthopedic diseases as well as to enhance the therapeutic efficacy. It has been found that metal-organic frameworks (MOFs) possess the advantages of high specific surface area, high porosity, chemical stability, tunability of structure and biocompatibility. Therefore, MOFs are expected to improve the conventional traditional treatment modality for bone diseases. This manuscript reviewed the applications of MOFs in the treatment of common clinical bone diseases and look forward to its future development.

Keywords: MOFs; metal-organic frameworks; osteoarthritis; osteoporosis; tumor.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work has been financially supported by the Health Industry Clinical Research Project of Shanghai Health Commission (Grant No. 20224Y0393), the Young Medical Talents Training Program of Pudong Health Committee of Shanghai (Grant No. PWRq 2021-08), the Science and Technology Development Fund of Shanghai Pudong New Area (Grant No. PKJ2023-Y09), the Outstanding Leaders Training Program of Pudong Hospital affiliated to Fudan University (Grant No. LX202201), the Project of Key Medical Specialty and Treatment Center of Pudong Hospital of Fudan University (Grant No. Tszb2023-05), the Outstanding Clinical Discipline Project of Shanghai Pudong (Grant No. PWYgy2021-04), the Project of Key Medical Specialty and Treatment Center of Pudong Hospital of Fudan University (Zdzk2020-02, Zdzk2021-01).