Association Between High-Sensitivity C-Reactive Protein (hs-CRP) Levels With Lipids and Micronutrients

Cureus. 2024 Aug 20;16(8):e67268. doi: 10.7759/cureus.67268. eCollection 2024 Aug.

Abstract

Background and aims: Elevated high-sensitivity C-reactive protein (hs-CRP) levels are associated with an increased risk of cardiovascular disease, indicating systemic inflammation. Abnormal lipid levels and deficiencies in certain vitamins and minerals could also contribute to elevated hs-CRP levels. By broadly looking at the cross-correlations between inflammatory, lipid, and micronutrient markers, we aim to highlight the key associations at the serological levels.

Methods: A retrospective analysis was conducted on 1,014 free-living individuals who tested for cardiovascular and micronutrient panels along with hs-CRP at Vibrant America Clinical Laboratory.

Results and conclusion: Based on parametric t-tests, significant variations between the sexes (Ma1) were observed for cholesterol, high-density lipoprotein (HDL), triglycerides, vitamin A, vitamin D3, serum copper, and valine. Pearson's correlation showed a high-significant positive correlation between hs-CRP and triglycerides, folate, serum copper, and manganese.

Keywords: cholesterol; hs-crp; lipids; micronutrients; systemic inflammation; vitamins.