Transcription regulation through selective partitioning: Weak interactions with a strong foundation

Megan Palacio; Dylan J Taatjes

doi:10.1016/j.molcel.2024.08.029

Transcription regulation through selective partitioning: Weak interactions with a strong foundation

Mol Cell. 2024 Sep 19;84(18):3375-3377. doi: 10.1016/j.molcel.2024.08.029.

Authors

Megan Palacio¹, Dylan J Taatjes²

Affiliations

¹ Department of Biochemistry, University of Colorado, Boulder, CO 80303, USA.
² Department of Biochemistry, University of Colorado, Boulder, CO 80303, USA. Electronic address: [email protected].

PMID: 39303678
DOI: 10.1016/j.molcel.2024.08.029

Abstract

In this issue of Molecular Cell, De La Cruz, Pradhan, Veettil et al.¹ examine how selective partitioning of proteins via low-affinity IDR-dependent interactions may help regulate RNA polymerase II (RNA Pol II) function and identify sequence features that drive partitioning in cells.

MeSH terms

Gene Expression Regulation
Humans
Intrinsically Disordered Proteins / chemistry
Intrinsically Disordered Proteins / genetics
Intrinsically Disordered Proteins / metabolism
Protein Binding
RNA Polymerase II* / genetics
RNA Polymerase II* / metabolism
Transcription, Genetic*

Substances

RNA Polymerase II
Intrinsically Disordered Proteins

Grants and funding

R35 GM139550/GM/NIGMS NIH HHS/United States