Akkermansia in the gastrointestinal tract as a modifier of human health

Gut Microbes. 2024 Jan-Dec;16(1):2406379. doi: 10.1080/19490976.2024.2406379. Epub 2024 Sep 21.

Abstract

Akkermansia sp are common members of the human gut microbiota. Multiple reports have emerged linking the abundance of A. muciniphila to health benefits and disease risk in humans and animals. This review highlights findings linking Akkermansia species in the gastrointestinal (GI) tract to health outcomes across a spectrum of disorders, encompassing those that affect the digestive, respiratory, urinary, and central nervous systems. The mechanism through which Akkermansia exerts a beneficial versus a detrimental effect on health is likely dependent on the genetic makeup of the host metabolic capacity and immunomodulatory properties of the strain, the competition or cooperation with other members of the host microbiota, as well as synergy with co-administered therapies.

Keywords: AD; ALS; ASD; Akkermansia muciniphila; CKD; Clostridium difficile; GVHD; IBD; LCMV; MS; NAFLD; PD; Salmonella typhimurium; asthma; biwaensis; cancer; diabetes; durhamii; epilepsy; helminth; ignis; immunotherapy; infections; influenza; liver; massiliensis; microbiota; nephropathy; neurological disease; obesity; sepsis; tuberculosis.

Publication types

  • Review

MeSH terms

  • Akkermansia* / physiology
  • Animals
  • Gastrointestinal Diseases / microbiology
  • Gastrointestinal Microbiome*
  • Gastrointestinal Tract* / microbiology
  • Humans

Supplementary concepts

  • Akkermansia muciniphila