INCIDENCE OF STEROID-RELATED OCULAR HYPERTENSION AND CATARACT FORMATION AFTER SUB-TENON TRIAMCINOLONE IN NONUVEITIC PEDIATRIC PATIENTS

Retina. 2025 Jan 1;45(1):141-146. doi: 10.1097/IAE.0000000000004272.

Abstract

Purpose: To describe intraocular pressure changes after injection of sub-Tenon triamcinolone during examination under anesthesia for pediatric patients.

Methods: Multicenter, retrospective case series of pediatric patients who received sub-Tenon triamcinolone from three tertiary care ophthalmic services between November 2018 and October 2023.

Results: Of 392 patients identified, 59 eyes (10.5%) of 41 patients were included. Laser was administered in 95.1% of the cases. Sub-Tenon triamcinolone dose ranged from 4 to 20 mg. The most common diagnosis was retinopathy of prematurity (43.9%). Two eyes (3.4%) of two patients (4.9%) were mild steroid responders. One eye (1.7%) of 1 patient (2.4%) was a moderate responder. There were no high steroid responders, and all eyes with steroid response showed a return of intraocular pressure to normal range at next visit without needing any intraocular pressure-lowering medications. No patients were diagnosed with glaucoma or required glaucoma surgery. Only 1 eye (1.7%) developed trace posterior subcapsular cataract, whereas no optic disk cupping or inflammation were noted.

Conclusion: Sub-Tenon triamcinolone injection is commonly used to prevent inflammation at the time of retinal photocoagulation treatment in pediatric patients. It has a favorable safety profile in relation to intraocular pressure elevation and cataract formation. There was no requirement for intraocular pressure-lowering medications or surgical interventions.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Cataract* / chemically induced
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Glucocorticoids* / administration & dosage
  • Glucocorticoids* / adverse effects
  • Humans
  • Incidence
  • Infant
  • Injections, Intraocular
  • Intraocular Pressure* / drug effects
  • Intraocular Pressure* / physiology
  • Male
  • Ocular Hypertension* / chemically induced
  • Ocular Hypertension* / physiopathology
  • Retrospective Studies
  • Tenon Capsule / drug effects
  • Triamcinolone Acetonide* / administration & dosage
  • Triamcinolone Acetonide* / adverse effects

Substances

  • Glucocorticoids
  • Triamcinolone Acetonide