Development of a recombinant non-replicating Newcastle disease virus

Avian Pathol. 2025 Feb;54(1):149-157. doi: 10.1080/03079457.2024.2403412. Epub 2024 Sep 25.

Abstract

Development of nr-NDV.Reverse transfection was applied for the recovery of nr-NDV.Propagation of nr-NDV was done by sub-passaging transfected BSR T7/5 cells.Safety profile was done to prove that the nr-NDV is non-replicating.

Keywords: Newcastle disease virus; avian virus; non-replicating; reverse genetic system; truncated anti-genome; viral vector.

MeSH terms

  • Animals
  • Cell Line
  • Chickens / virology
  • Newcastle disease virus* / genetics
  • Recombination, Genetic
  • Transfection / veterinary
  • Virus Replication