Inflammatory and Immune Mechanisms in COPD: Current Status and Therapeutic Prospects

Yanan Qi; Yuanyuan Yan; Dawei Tang; Jingjing Han; Xinyi Zhu; Mengting Cui; Hongyan Wu; Yu Tao; Fangtian Fan

doi:10.2147/JIR.S478568

Inflammatory and Immune Mechanisms in COPD: Current Status and Therapeutic Prospects

J Inflamm Res. 2024 Sep 20:17:6603-6618. doi: 10.2147/JIR.S478568. eCollection 2024.

Authors

Yanan Qi^{1

2}, Yuanyuan Yan^{1

2}, Dawei Tang^{1

2}, Jingjing Han^{1

2}, Xinyi Zhu^{1

2}, Mengting Cui^{1

2}, Hongyan Wu³, Yu Tao^{1

2}, Fangtian Fan^{1

2}

Affiliations

¹ School of Pharmacy, Bengbu Medical University, Bengbu, People's Republic of China.
² Anhui Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu, People's Republic of China.
³ Institute of Biomedical Technology, Jiangsu Vocational College of Medicine, Yancheng, Jiangsu, 224005, People's Republic of China.

Abstract

Background: Chronic obstructive pulmonary disease (COPD) currently ranks among the top three causes of mortality worldwide, presenting as a prevalent and complex respiratory ailment. Ongoing research has underscored the pivotal role of immune function in the onset and progression of COPD. The immune response in COPD patients exhibits abnormalities, characterized by diminished anti-infection capacity due to immune senescence, heightened activation of neutrophils and macrophages, T cell infiltration, and aberrant B cell activity, collectively contributing to airway inflammation and lung injury in COPD.

Objective: This review aimed to explore the pivotal role of the immune system in COPD and its therapeutic potential.

Methods: We conducted a review of immunity and COPD published within the past decade in the Web of Science and PubMed databases, sorting through and summarizing relevant literature.

Results: This article examines the pivotal roles of the immune system in COPD. Understanding the specific functions and interactions of these immune cells could facilitate the development of novel therapeutic strategies and interventions aimed at controlling inflammation, enhancing immune function, and mitigating the impact of respiratory infections in COPD patients.

Keywords: COPD; immune regulation; immune system; inflammation.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China (Grant/Award Numbers: 81973658, 82274339, 82104487); Bengbu Medical College Major Science and Technology Project Incubation Program (Grant/Award Numbers: 2020byfy001); Jiangsu Province Engineering Research Center for Cardiovascular and Cerebrovascular Disease and Cancer Prevention and Control (2022); University Natural Science Research Project of Anhui Province (Grant/Award Numbers: 2023AH051972); Jiangsu Higher Education Institution Innovative Research Team For Science and Technology (2023). Excellent scientific research and innovation team project of Anhui Province (Grant/Award Numbers: 2022AH010084).