Incidental Detection of Brain Metastases From a Pulmonary Large Cell Neuroendocrine Carcinoma at 18 F-Fluorocholine PET/CT in a Context of Primary Hyperparathyroidism

Clin Nucl Med. 2024 Nov 1;49(11):e625-e627. doi: 10.1097/RLU.0000000000005470. Epub 2024 Sep 25.

Abstract

This 65-year-old man suffering from hypercalcemia in a context of hyperparathyroidism treated by calcimimetics was referred to our institution to perform an 18 F-fluorocholine PET/CT in order to localize the pathological parathyroid gland(s). We incidentally discovered a brain metastatic pulmonary large cell neuroendocrine carcinoma in addition to a parathyroid adenoma. This case illustrates the value of FCH PET/CT in hyperparathyroidism workup event under calcimimetic treatment, as well as the potential of FCH PET/CT to reveal occult malignancies.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Brain Neoplasms* / diagnostic imaging
  • Brain Neoplasms* / secondary
  • Carcinoma, Large Cell / diagnostic imaging
  • Carcinoma, Large Cell / secondary
  • Carcinoma, Neuroendocrine* / diagnostic imaging
  • Carcinoma, Neuroendocrine* / secondary
  • Choline* / analogs & derivatives
  • Humans
  • Hyperparathyroidism, Primary* / diagnostic imaging
  • Incidental Findings*
  • Lung Neoplasms* / diagnostic imaging
  • Lung Neoplasms* / pathology
  • Male
  • Positron Emission Tomography Computed Tomography*
  • Tomography, X-Ray Computed

Substances

  • fluorocholine
  • Choline