Lipoleiomyosarcoma is a malignant tumor of both mesenchymal and smooth muscle origin. Lipoleiomyosarcoma is a very rare type of retroperitoneal sarcoma, which by itself is a rare type of soft tissue sarcoma. Lipoleiomyosarcoma is a very rare subtype of liposarcoma, which is the most common type of retroperitoneal sarcoma. To our best review of available literature, this was the first case of lipoleiomyosarcoma presenting as a massive retroperitoneal mass of size 50 × 50 × 30 cm, managed with multi-visceral R0 resection. The computed tomography of the abdomen showed a massive fat density lesion with internal soft density lesions and internal calcifications. Multivisceral resection was planned and executed and achieved R0 resection. We suggest that lipoleiomyosarcoma should be included in differential diagnosis of retroperitoneal tumors, and multi-visceral R0 resection should be considered as an option for lipoleiomyosarcoma, as these tumors have very good prognosis with R0 resection.
Keywords: Lipoleiomyosarcoma; Multivisceral resection; Retroperitoneal sarcoma; Soft tissue sarcoma.
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