A higher desmethylclomipramine to clomipramine ratio predicts more effectiveness and fewer adverse effects in major depressive disorder

Affiliations

• ¹ Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, the Netherlands; Antes, Parnassia Group, Rotterdam, the Netherlands. Electronic address: [email protected].
• ² Department of Clinical Chemistry, Erasmus University Medical Centre, Rotterdam, the Netherlands.
• ³ Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, the Netherlands.
• ⁴ Department of Pharmacy, Radboud University Medical Center, Nijmegen, the Netherlands.
• ⁵ Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands; Nijmegen Institute for Scientist Practitioners in Addiction (NISPA), Radboud University, Nijmegen, the Netherlands.
• ⁶ Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands.