Engineering next-generation oxygen-generating scaffolds to enhance bone regeneration

Jingtong Zhao; Naboneeta Sarkar; Yunke Ren; Arvind P Pathak; Warren L Grayson

doi:10.1016/j.tibtech.2024.09.006

Engineering next-generation oxygen-generating scaffolds to enhance bone regeneration

Trends Biotechnol. 2024 Sep 28:S0167-7799(24)00250-6. doi: 10.1016/j.tibtech.2024.09.006. Online ahead of print.

Authors

Jingtong Zhao¹, Naboneeta Sarkar¹, Yunke Ren¹, Arvind P Pathak², Warren L Grayson³

Affiliations

¹ Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD, USA.
² Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD, USA; Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA; Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, USA.
³ Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD, USA; Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, USA; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA. Electronic address: [email protected].

PMID: 39343620
DOI: 10.1016/j.tibtech.2024.09.006

Abstract

In bone, an adequate oxygen (O₂) supply is crucial during development, homeostasis, and healing. Oxygen-generating scaffolds (OGS) have demonstrated significant potential to enhance bone regeneration. However, the complexity of O₂ delivery and signaling in vivo makes it challenging to tailor the design of OGS to precisely meet this biological requirement. We review recent advances in OGS and analyze persisting engineering and translational hurdles. We also discuss the potential of computational and machine learning (ML) models to facilitate the integration of novel imaging data with biological readouts and advanced biomanufacturing technologies. By elucidating how to tackle current challenges using cutting-edge technologies, we provide insights for transitioning from traditional to next-generation OGS to improve bone regeneration in patients.

Keywords: biomaterials; computational modeling; hypoxia; imaging; machine learning; oxygen generation.

Publication types

Review

Grants and funding

R01 DE027957/DE/NIDCR NIH HHS/United States