Abstract
Ro 15-8074, a new cephalosporin the pivaloyloxymethylester of which (Ro 15-8075) is orally absorbable, showed greater in vitro activity than cefaclor against 48 Neisseria gonorrhoeae strains, including 25 penicillinase-producing strains. Unlike cefaclor, Ro 15-8074 was unaffected by increase in inoculum size, and it exhibited a remarkable stability against gonococcal beta-lactamase hydrolysis.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amoxicillin / metabolism
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Amoxicillin / pharmacology
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Amoxicillin-Potassium Clavulanate Combination
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Cefaclor / metabolism
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Cefaclor / pharmacology
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Ceftizoxime* / analogs & derivatives*
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Cephalosporins / metabolism
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Cephalosporins / pharmacology*
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Clavulanic Acids / pharmacology
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In Vitro Techniques
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Microbial Sensitivity Tests
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Neisseria gonorrhoeae / drug effects*
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beta-Lactamases / metabolism
Substances
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Cephalosporins
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Clavulanic Acids
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cefetamet
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Cefaclor
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Amoxicillin-Potassium Clavulanate Combination
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Amoxicillin
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Ceftizoxime
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beta-Lactamases
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cefetamet pivoxyl