Tract-specific magnetization transfer ratio provides insights into the severity of degenerative cervical myelopathy

Grace Haynes; Fauziyya Muhammad; Kenneth A Weber 2nd; Ali F Khan; Sanaa Hameed; Hakeem Shakir; Michael Van Hal; Douglas Dickson; Michael Rohan; Yasin Dhaher; Todd Parrish; Lei Ding; Zachary A Smith

doi:10.1038/s41393-024-01036-y

Tract-specific magnetization transfer ratio provides insights into the severity of degenerative cervical myelopathy

Spinal Cord. 2024 Oct 1. doi: 10.1038/s41393-024-01036-y. Online ahead of print.

Authors

Affiliations

¹ Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, USA. [email protected].
² Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
³ Division of Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
⁴ Department of Orthopedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
⁵ Laureate Institute of Brain Research, Tulsa, OK, USA.
⁶ Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, TX, USA.
⁷ Department of Radiology, Northwestern Feinberg School of Medicine, Chicago, IL, USA.
⁸ Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, USA.

PMID: 39354176
DOI: 10.1038/s41393-024-01036-y

Abstract

Study design: Cross-sectional study.

Objectives: This study's goal is to report whether Magnetization Transfer Ratio (MTR) can evaluate the severity of white matter (WM) injury in degenerative cervical myelopathy (DCM).

Setting: Laureate Institute of Brain Research, USA; Department of Neurosurgery, University of Oklahoma Health Sciences Center, USA.

Methods: 27 DCM patients were aged-matched with 20 healthy controls (HC) and categorized into treatment groups based on modified Japanese Orthopedic Association (mJOA) severity (11 mild and 16 moderate/severe). Regional and tract MTRs were extracted from the two vertebral levels containing maximum compression within magnetization transfer images. MTR differences between groups were assessed using a one-way ANOVA or Kruskal-Wallis test. The association between MTR and mJOA measures was evaluated using Spearman's correlation.

Results: Significant decreases in MTR were found between HC and moderate/severe groups in the overall (p = 0.0065) and ventral (p = 0.0009) WM regions; and ventral corticospinal (p = 0.0101), ventral reticulospinal (p = 0.0084), spinal lemniscus (p = 0.0079), and fasciculus cuneatus (p = 0.0219) tracts. The spinal lemniscus MTR also significantly decreased between HC and mild groups (p = 0.038). Ventral reticulospinal tract MTR correlated with upper (r = 0.439; p = 0.022) and lower (r = 0.386; p = 0.047) limb motor mJOA scores.

Conclusions: Significant tract-based MTR changes and correlations align with known DCM symptoms, are demonstrated to be lost at the regional level, and display the inhomogeneous compressive damage occurring within DCM spinal cords.

Abstract

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