Dauricine: Review of Pharmacological Activity

Drug Des Devel Ther. 2024 Sep 27:18:4371-4385. doi: 10.2147/DDDT.S471352. eCollection 2024.

Abstract

Background: Dauricine is an important natural organic compound in Menispermum dauricum, which often has significant biological activity.

Purpose: The purpose of this review is to systemically summarize and discuss the pharmacological activity and underlying mechanisms of dauricine in recent years.

Methods: Web of Science (121 articles) and PubMed databases (97 articles) were used to search for articles related to "dauricine" published from 2000 to 2024. Meanwhile, we classified the pharmacological activity of dauricine by screening these articles.

Results: Emerging evidence suggests that dauricine possesses numerous pharmacological activities, including neuroprotection, anti-cancer, anti-arrhythmia, anti-inflammatory and anti-diabetes.

Conclusion: Dauricine has a potential value in the treatment of many diseases. We hope that this review will contribute to therapeutic development and future studies of dauricine.

Keywords: dauricine; menispermum dauricum; pharmacokinetics; pharmacology; toxicity.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Arrhythmia Agents / chemistry
  • Anti-Arrhythmia Agents / pharmacology
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Benzylisoquinolines* / chemistry
  • Benzylisoquinolines* / pharmacology
  • Humans
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / pharmacology
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / pharmacology
  • Tetrahydroisoquinolines* / chemistry
  • Tetrahydroisoquinolines* / pharmacology

Substances

  • Benzylisoquinolines
  • dauricine
  • Tetrahydroisoquinolines
  • Neuroprotective Agents
  • Anti-Arrhythmia Agents
  • Hypoglycemic Agents
  • Anti-Inflammatory Agents
  • Antineoplastic Agents

Grants and funding

There is no funding to report.