A new texture-based labeling framework for hyper-reflective foci identification in retinal optical coherence tomography images

Sci Rep. 2024 Oct 2;14(1):22933. doi: 10.1038/s41598-024-73927-2.

Abstract

An important abnormality in Optical Coherence Tomography (OCT) images is Hyper-Reflective Foci (HRF). This anomaly can be interpreted as a biomarker of serious retinal diseases such as Age-related Macular Degeneration (AMD) and Diabetic Macular Edema (DME) or the progression of disease from an early stage to a late one. In this paper, a new method is proposed for the identification of HRFs. The new method divides the OCT B-scan into patches and separately verifies each patch to determine whether or not the patch contains an HRF. The procedure of patch verification contains a texture-based framework which assigns appropriate labels according to intensity changes to each column and row. Then, a feature vector is extracted for each patch based on the assigned labels. The feature vectors are utilized in the training step of well-known classifiers like Support Vector Machine (SVM). Then, the classifiers are used to produce the labels for the test OCT images. The new method is evaluated on a public dataset including HRF labels. The experimental results show that the new method is capable of providing outstanding results in terms of speed and accuracy.

MeSH terms

  • Algorithms
  • Diabetic Retinopathy / diagnostic imaging
  • Humans
  • Image Processing, Computer-Assisted / methods
  • Macular Degeneration / diagnostic imaging
  • Macular Degeneration / pathology
  • Macular Edema / diagnostic imaging
  • Retina* / diagnostic imaging
  • Retina* / pathology
  • Retinal Diseases / diagnostic imaging
  • Retinal Diseases / pathology
  • Support Vector Machine*
  • Tomography, Optical Coherence* / methods