Successful Simultaneous Heart-Kidney Transplant in a Patient With MT-TL1 MELAS Cardiomyopathy

Jose Arriola-Montenegro; Melinda Mutschler; Rebecca Cogswell; Tamas Alexy; Ranjit John; Rochus Voeller; Vanessa Humphreville; Anjali Aggarwal; Valmiki Maharaj

doi:10.1016/j.jaccas.2024.102523

Successful Simultaneous Heart-Kidney Transplant in a Patient With MT-TL1 MELAS Cardiomyopathy

JACC Case Rep. 2024 Sep 18;29(18):102523. doi: 10.1016/j.jaccas.2024.102523.

Authors

Jose Arriola-Montenegro¹, Melinda Mutschler², Rebecca Cogswell², Tamas Alexy², Ranjit John³, Rochus Voeller³, Vanessa Humphreville⁴, Anjali Aggarwal⁵, Valmiki Maharaj²

Affiliations

¹ Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
² Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
³ Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, Minnesota.
⁴ Division of Transplant Surgery, Department of Surgery, University of Minnesota, Minnesota.
⁵ Division of Genetics and Metabolism, Department of Pediatrics, University of Minnesota, Minnesota.

Abstract

Here we describe the first reported case of a patient with MT-TL1:m.3243A>G MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes)-associated cardiomyopathy who successfully underwent simultaneous heart-kidney transplantation.

Keywords: MELAS; heart failure; kidney failure; transplant.

Publication types

Case Reports