Aberrant tau condensates as catalytic microcompartments propel tau fibrillation

Agustín Mangiarotti; Asima Nayak; Dragomir Milovanovic

doi:10.1016/j.str.2024.09.004

Aberrant tau condensates as catalytic microcompartments propel tau fibrillation

Structure. 2024 Oct 3;32(10):1547-1549. doi: 10.1016/j.str.2024.09.004.

Authors

Agustín Mangiarotti¹, Asima Nayak¹, Dragomir Milovanovic²

Affiliations

¹ Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany.
² Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany. Electronic address: [email protected].

PMID: 39366336
DOI: 10.1016/j.str.2024.09.004

Abstract

In this issue of Structure, Soeda et al.¹ employed optogenetic tools and demonstrate that an N-terminal truncation of tau and microtubule-binding deficiency lead to the formation of tau condensates, accelerating its fibrillation.

MeSH terms

Humans
Microtubules / metabolism
Optogenetics
tau Proteins* / chemistry
tau Proteins* / genetics
tau Proteins* / metabolism

Substances

tau Proteins