One RING to rule them all: Mind bomb-1 ccRING3 controls Notch signaling

Kristen M Ramsey; Doug Barrick

doi:10.1016/j.str.2024.09.009

One RING to rule them all: Mind bomb-1 ccRING3 controls Notch signaling

Structure. 2024 Oct 3;32(10):1550-1551. doi: 10.1016/j.str.2024.09.009.

Authors

Kristen M Ramsey¹, Doug Barrick²

Affiliations

¹ T.C. Jenkins Department of Biophysics, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21209, USA. Electronic address: [email protected].
² T.C. Jenkins Department of Biophysics, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21209, USA.

PMID: 39366337
DOI: 10.1016/j.str.2024.09.009

Abstract

In this issue of Structure, Cao et al.¹ use X-ray crystallography, biochemical, and genetic studies to define the key role of the Mind bomb-1 ccRING3 domain in triggering Notch signaling, and they demonstrate that ccRING3-mediated dimerization is a key step in ligand activation.

MeSH terms

Animals
Crystallography, X-Ray
Humans
Protein Domains
Protein Multimerization
Receptors, Notch* / chemistry
Receptors, Notch* / metabolism
Signal Transduction*

Substances

Receptors, Notch