Timing is everything: When is m6A deposited?

David Dierks; Schraga Schwartz

doi:10.1016/j.molcel.2024.09.012

Timing is everything: When is m6A deposited?

Mol Cell. 2024 Oct 3;84(19):3572-3573. doi: 10.1016/j.molcel.2024.09.012.

Authors

David Dierks¹, Schraga Schwartz²

Affiliations

¹ Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
² Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel. Electronic address: [email protected].

PMID: 39366343
DOI: 10.1016/j.molcel.2024.09.012

Abstract

In this issue of Molecular Cell, Tang et al. suggest that m6A deposition is predominantly post-transcriptional.¹ They further propose that nuclear dwell time dictates the post-transcriptional accumulation of m6A. These findings have important implications for m6A biogenesis and function.

Publication types

Comment

MeSH terms

Adenosine* / analogs & derivatives
Adenosine* / metabolism
Animals
Cell Nucleus / genetics
Cell Nucleus / metabolism
Humans
RNA Processing, Post-Transcriptional
RNA, Messenger / genetics
RNA, Messenger / metabolism
Time Factors

Substances

Adenosine
N-methyladenosine
RNA, Messenger