Let's get functional: Drug sensitivity profiling to enable precision sarcoma medicine

Cell Stem Cell. 2024 Oct 3;31(10):1389-1390. doi: 10.1016/j.stem.2024.09.006.

Abstract

Drug sensitivity profiling in patient-derived tumor models offers new hope for improving outcomes in cancers lacking effective therapies. Al Shihabi et al.1 demonstrate that short-term cultures from bone and soft tissue sarcomas enable clinically meaningful screening of multiple drugs and combinations, marking a significant advance in personalized care for these high-risk diseases.

MeSH terms

  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Drug Screening Assays, Antitumor
  • Humans
  • Precision Medicine*
  • Sarcoma* / drug therapy
  • Sarcoma* / pathology

Substances

  • Antineoplastic Agents