Discovery of a selective cytochrome P450 4A inhibitor for the treatment of metabolic dysfunction-associated fatty liver disease

Minji Lee; Myung Jin Son; Sin-Hyoung Hong; Jae-Sung Ryu; Ji-Hyeon Min; Dong-Eon Lee; Ji Hoon Lee; Nam Doo Kim; Shi-Young Park; Darong Kim; Jeongmin Joo; Jisung Kwak; Kook Hwan Kim; Yong-Ho Lee; Byeong-Rak Keum; Hyun Seok Song; Youngae Jung; Koon Soon Kim; Gun-Hwa Kim

doi:10.1002/ctm2.1816

Discovery of a selective cytochrome P450 4A inhibitor for the treatment of metabolic dysfunction-associated fatty liver disease

Clin Transl Med. 2024 Oct;14(10):e1816. doi: 10.1002/ctm2.1816.

Authors

Minji Lee^#¹, Myung Jin Son^#^{2

3

4}, Sin-Hyoung Hong^#¹, Jae-Sung Ryu⁵, Ji-Hyeon Min^{1

6}, Dong-Eon Lee^{1

7}, Ji Hoon Lee⁸, Nam Doo Kim⁹, Shi-Young Park¹⁰, Darong Kim⁸, Jeongmin Joo⁸, Jisung Kwak^{11

12}, Kook Hwan Kim¹³, Yong-Ho Lee¹⁴, Byeong-Rak Keum¹⁵, Hyun Seok Song¹¹, Youngae Jung¹⁶, Koon Soon Kim¹⁷, Gun-Hwa Kim^{1

6

7

18}

Affiliations

¹ Digital Omics Research Center, Korea Basic Science Institute (KBSI), Cheongju, Republic of Korea.
² Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea.
³ Department of Functional Genomics, Korea University of Science & Technology (UST), Daejeon, Republic of Korea.
⁴ School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.
⁵ New Drug Development Center, Osong Medical Innovation Foundation, Cheongju, Republic of Korea.
⁶ Department of Analytical Science and Technology, Graduate School of Analytical Science and Technology (GRAST), Chungnam National University, Daejeon, Republic of Korea.
⁷ Department of Bio-Analytical Science, University of Science and Technology (UST), Daejeon, Republic of Korea.
⁸ New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea.
⁹ New Drug Discovery & Development, VORONOIBIO Inc., Incheon, Republic of Korea.
¹⁰ Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, South Korea.
¹¹ Sensor System Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
¹² Department of Chemical and Biological Engineering, Korea University, Seoul, Republic of Korea.
¹³ Discovery Division, GI Innovation, Inc., Seoul, South Korea.
¹⁴ Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
¹⁵ Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.
¹⁶ Integrated Metabolomics Research Group, Metropolitan Seoul Center, Korea Basic Science Institute (KBSI), Seoul, Republic of Korea.
¹⁷ Division of Endocrinology and Metabolism, Daejeon Endo Internal Medicine, Daejeon, Republic of Korea.
¹⁸ Research and Development Center, CYPHARMA, Daejeon, Republic of Korea.

^# Contributed equally.

No abstract available

Publication types

Letter

MeSH terms

Animals
Cytochrome P-450 Enzyme Inhibitors / pharmacology
Cytochrome P-450 Enzyme Inhibitors / therapeutic use
Humans
Metabolic Diseases / drug therapy
Metabolic Diseases / metabolism
Non-alcoholic Fatty Liver Disease* / drug therapy
Non-alcoholic Fatty Liver Disease* / metabolism

Substances

Cytochrome P-450 Enzyme Inhibitors

Publication types

MeSH terms

Substances

Grants and funding