Seizures and Epilepsy in Association With Neurocysticercosis: A Nosologic Proposal

Neurology. 2024 Nov 12;103(9):e209865. doi: 10.1212/WNL.0000000000209865. Epub 2024 Oct 7.

Abstract

Neurocysticercosis is one of the main risk factors of seizures and epilepsy in many regions of the world, which are Taenia solium-endemic but resource-constrained to control the parasite. The nosology of seizures and the classification of epilepsy in the context of neurocysticercosis are somewhat uncertain. Many seizures associated with the infection are customarily referred to as "acute symptomatic seizures." The term, however, seems unsuitable. Neither is the condition acute nor does it allow the avoidance of long-term antiseizure medications, as is the case with acute symptomatic seizures, for instance, associated with traumatic brain injury. We propose that seizures be classified according to the evolutionary stage of parenchymal cysticercosis in addition to the conventional classification of seizures and epilepsy and identification of the epileptogenic zone. An often-ignored aspect is the identification of comorbidities, many of which are specific to neurocysticercosis.

MeSH terms

  • Animals
  • Epilepsy* / etiology
  • Humans
  • Neurocysticercosis* / complications
  • Neurocysticercosis* / diagnostic imaging
  • Seizures* / etiology
  • Taenia solium