The Effect of Premedication with Metoprolol on the Surgical Field during Endoscopic Stapedectomy

Mostafa Nasr Zayed; Khaled Mohamed Abdelzaher; Mokhtar Mostafa Mahran; Ahmed Adel Sadek

doi:10.1007/s12070-024-04878-3

The Effect of Premedication with Metoprolol on the Surgical Field during Endoscopic Stapedectomy

Indian J Otolaryngol Head Neck Surg. 2024 Oct;76(5):4411-4416. doi: 10.1007/s12070-024-04878-3. Epub 2024 Jul 22.

Authors

Mostafa Nasr Zayed¹, Khaled Mohamed Abdelzaher¹, Mokhtar Mostafa Mahran², Ahmed Adel Sadek¹

Affiliations

¹ department of otorhinolaryngology, faculty of medicine, El Minia, Egypt.
² department of Anaesthesia, faculty of medicine, El Minia, Egypt.

PMID: 39376332
PMCID: PMC11456138 (available on 2025-10-01)
DOI: 10.1007/s12070-024-04878-3

Abstract

Background: Otosclerosis is one of the most frequent causes of conductive hearing loss in adults. Surgical treatment is considered to be the gold standard for this disease. Endoscopic stapedectomy is a new approach for the treatment of otosclerosis that requires a bloodless field.

Aim of the study: To determine whether the routine use of β blockers as a premedication can improve the operative field in endoscopic stapedectomy or not.

Patients and methods: Sixty patients aged from 18 to 50 years, undergoing endoscopic stapedectomy, were included in this prospective, randomized, double blinded, placebo-controlled study. Patients were randomly assigned to receive either metoprolol 100 mg ( group 1) or a placebo, vitamin tablet, (group 2) 60 min before surgery.

Results: The age, gender, body weight and ASA physical status were comparable between the two groups. The average blood loss in the placebo group was significantly greater than in the metoprolol group, but the time of operation in the metoprolol group was not significantly shorter. The surgical field was assessed using the Fromme-Boezaart scale, and those who received metoprolol had considerably cleaner (p0.001) surgical fields. The mean arterial pressure (MAP) didn't differ statistically significant at basal measurement up to 30 min after anesthesia induction while it was significantly lower in the metoprolol group after 30 min of induction up to end of surgery (p < 0.001). The heart rate was also significantly lower (p < 0.001) in patients who received metoprolol from prior to anesthesia induction up to end of surgery.

Conclusion: metoprolol significantly improves visual clarity and hemodynamics during endoscopic stapedectomy.

Keywords: MAP; Metoprolol; Stapedectomy.

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