Abstract
The supramolecular palladium complex G-Pd, formed via self-assembly of the Pd-complex of guanidinium pillar[5]arene with Pd2+, was used to encapsulate doxorubicin to form G-Pd@DOX. The nanoparticles exhibit responsiveness to glutathione, controlled drug release, the ability to damage mitochondria, and potent anticancer activity while maintaining low toxicity towards normal cells. This work provides a good example for the application of pillararene-based palladium complexes in cancer therapy and is significant for the discovery of new medicines from supramolecular coordination complexes.
MeSH terms
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Antineoplastic Agents* / chemistry
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Antineoplastic Agents* / pharmacology
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Calixarenes* / chemistry
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Cell Line, Tumor
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Cell Survival / drug effects
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Coordination Complexes* / chemical synthesis
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Coordination Complexes* / chemistry
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Coordination Complexes* / pharmacology
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Doxorubicin* / chemistry
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Doxorubicin* / pharmacology
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Drug Liberation
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Drug Screening Assays, Antitumor
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Glutathione / chemistry
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Guanidine* / chemistry
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Guanidine* / pharmacology
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Humans
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Palladium* / chemistry
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Quaternary Ammonium Compounds / chemistry
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Quaternary Ammonium Compounds / pharmacology
Substances
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Palladium
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Doxorubicin
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pillar(5)arene
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Calixarenes
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Guanidine
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Coordination Complexes
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Antineoplastic Agents
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Quaternary Ammonium Compounds
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Glutathione