Early Life Exposure to Parental Crohn's Disease Is Associated With Offspring's Gut Microbiome, Gut Permeability, and Increased Risk of Future Crohn's Disease
Gastroenterology. 2024 Oct 9:S0016-5085(24)05539-2.
doi: 10.1053/j.gastro.2024.09.033.
Online ahead of print.
1 Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada. Electronic address: [email protected].
2 Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.
3 Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.
4 Inflammatory Bowel Disease Centre, The Hospital for Sick Children, Temerty Faculty of Medicine, Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.
5 Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada. Electronic address: [email protected].
6 Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.
7 Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Biostatistics Department, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
8 Hopital Maisonneuve-Rosemont Un Montréal, Montréal, Québec, Canada.
9 University of Alberta, Edmonton, Alberta, Canada.
10 University of Calgary, Calgary, Alberta, Canada.
11 Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
12 Division of Gastroenterology, Hepatology & Nutrition, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, Ontario, Canada.
13 Department of Medicine, McMaster University, Farncombe Family Digestive Health Research Institute, Hamilton, Ontario, Canada.
14 Gastrointestinal Diseases Research Unit, Department of Medicine, Queen's University, Kingston, Ontario, Canada.
15 Division of Gastroenterology and Hepatology, McGill University and McGill University Health Centre (MUHC), Montréal, Québec, Canada.
16 British Columbia Children's Hospital, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
17 General Hospital, Health Sciences Centre, St. John's, Newfoundland, Canada.
18 Pediatric Gastroenterology Unit, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
19 Division of Gastroenterology, Crohn's and Colitis Center, Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida.
20 University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre and Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Winnipeg, Canada.
21 Queensland Institute of Medical Research, Berghofer Medical Research Institute, Herston, Brisbane, Australia.
22 University of Edinburgh, Edinburgh, Scotland.
23 The Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
24 Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Ontario, Canada.
25 Division of Gastroenterology, The Hospital for Sick Children, Toronto, Ontario, Canada.
26 Departments of Medicine, Epidemiology, and Biostatistics, University of Western Ontario, London, Ontario, Canada.
27 Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
28 Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.
29 Department of Pediatrics, Memorial University, St. John's, Newfoundland and Labrador, Canada.
30 Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
31 Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, Québec, Canada.
32 Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
33 Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
34 Connecticut Children's Medical Center Hartford, Connecticut.
35 Department of Pediatrics, IWK Health, Dalhousie University, Halifax, Nova Scotia, Canada.
36 Department of Gastroenterology, Dermatovenereology and Rheumatology, Karolinska University Hospital, Centre for Digestive Health, Stockholm, Sweden.
37 National Centre for Pediatric Gastroenterology, Children's Health Ireland, Dublin, Ireland.
38 Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
39 Gastroenterology Department, St James's Hospital, Dublin, Ireland.
40 Division of Gastroenterology, Department of Medicine, School of Medicine, University of California Irvine, Orange, California.
41 Division of Gastroenterology, Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, Hôtel-Dieu, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
42 Division of Pediatric Gastroenterology, Liver Disease, and Nutrition, Cohen Children's Medical Center of New York, Lake Success, New York.
43 Inflammatory Bowel Disease Center, University of Chicago Medicine, Chicago, Illinois.
44 Department of Medicine, University of Otago, Dunedin, New Zealand.
45 Center for Digestive Health, Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Centre, Lebanon, New Hampshire.