The landscape of Functional Outcome Measures Used in Patients with Bone Sarcoma of the Lower Extremity or Pelvis: A Systematic Review

Leonie G Tigelaar; Kiki J Blom; Willem P Bekkering; Jos A M Bramer; Hendrik W B Schreuder; Sherron Furtado; Craig H Gerrand; Emanuela Palmerini; Nathalie Gaspar; Sandra J Strauss; Michiel A J Van de Sande; Johannes H M Merks; Lianne M Haveman; FOSTER Consortium and the EuroEwing Consortium

doi:10.1002/jso.27921

The landscape of Functional Outcome Measures Used in Patients with Bone Sarcoma of the Lower Extremity or Pelvis: A Systematic Review

J Surg Oncol. 2024 Oct 10. doi: 10.1002/jso.27921. Online ahead of print.

Authors

Leonie G Tigelaar¹, Kiki J Blom^{1

2}, Willem P Bekkering^{1

3}, Jos A M Bramer^{1

2

4}, Hendrik W B Schreuder^{1

5}, Sherron Furtado⁶, Craig H Gerrand⁶, Emanuela Palmerini⁷, Nathalie Gaspar⁸, Sandra J Strauss⁹, Michiel A J Van de Sande^{1

10}, Johannes H M Merks^{1

11}, Lianne M Haveman¹; FOSTER Consortium and the EuroEwing Consortium

Affiliations

¹ Department of Solid Tumors, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
² Department of Orthopedic Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
³ Department of Quality of Life, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
⁴ Department of Orthopedic Surgery and Sports Medicine, Amsterdam Movement Sciences, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
⁵ Department of Orthopedic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
⁶ Department of Orthopedic Oncology, Royal National Orthopedic Hospital NHS Trust, Stanmore, UK.
⁷ Department of Medical Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
⁸ Department of Oncology for Child and Adolescent, Gustave Roussy Cancer Campus, Villejuif, France.
⁹ Department of Oncology, University College London Cancer Institute, London, UK.
¹⁰ Department of Orthopedic Surgery, Leiden University Medical Center, Leiden, The Netherlands.
¹¹ Division of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

PMID: 39387570
DOI: 10.1002/jso.27921

Abstract

This systematic review provides a structured overview of the measurement instruments of functional outcome used in lower extremity and pelvic bone sarcoma patients. We identified 42 unique instruments covering 18 distinct functional outcome constructs with most studies measuring constructs within the activity domain of the International Classification of Functioning, disability, and health. The MusculoSkeletal Tumor Society 1993 and 1987 score, Toronto Extremity Salvage Score, and range of motion instruments were the measurement instruments most commonly used.

Keywords: International Classification of Functioning, Disability and Health; functional status; neoplasms, bone tissue; outcome assessment, health care.

Publication types

Review

Grants and funding

The FOSTER consortium is supported by the "Enfants Cancers Sante (ECS)" and the "Societe Française de Lutte contre les Cancers et les Leucemies de L'Enfant et de L'Adolescent (SFCE)." The EuroEwing Consortium is supported by the Bone Cancer Research Trust.