Silicene, a two-dimensional allotrope of silicon, has attracted considerable attention due to its distinctive electronic, mechanical, and biochemical properties. This review critically examines the emerging applications of silicene in oncology, emphasising its potential roles in cancer therapy and research. Silicene exhibits exceptional biocompatibility and surface reactivity, positioning it as a promising candidate for oncological applications. This review addresses the current challenges and limitations in the clinical translation of silicene-based technologies, including issues of stability, toxicity, and scalable production. By synthesizing recent research findings, this review aims to provide an assessment of silicene's potential contributions to oncology and delineate future research trajectories in this innovative field.