Neonatal exposure to high D-galactose affects germ cell development in neonatal testes organ culture

Sci Rep. 2024 Oct 14;14(1):24029. doi: 10.1038/s41598-024-74895-3.

Abstract

Excess exogenous supplementation of D-galactose (D-gal), a monosaccharide and reducing sugar, generates reactive oxygen species (ROS), leading to cell damage and death. ROS accumulation is critical in aging. Therefore, D-gal-induced aging mouse models are used in aging studies. Herein, we evaluated D-gal's effect on neonatal testis development using an in vitro organ culture method. Mouse testicular fragments (MTFs) derived from neonatal testes (postnatal day 5) were cultured with 500 mM D-gal for 5 days. D-gal-treated MTFs showed a significantly increased and decreased expression of undifferentiated and differentiated germ cell markers, respectively, with a substantial reduction in meiotic cells. In D-gal-exposed MTFs, expression levels of Sertoli cell markers (Sox9 and Wt1) increased, while those of StAR and 17β-HSD3, whose expressions are abundant in D-Gal treated adult Leydig cells, decreased. Additionally, the enzyme 3 β-HSD1, essential for steroidogenesis in Leydig cells, was significantly reduced in D-gal-exposed MTFs compared to that in controls.D-gal significantly increased the expression of Bad, Bax, and cleaved caspase-3 and -8. Via oxidative stress in MTF. Overall, D-gal negatively regulates germ cell and Leydig cell development in neonatal testes through pro-apoptotic mechanisms and ROS.

MeSH terms

  • Animals
  • Animals, Newborn*
  • Apoptosis / drug effects
  • Cell Differentiation / drug effects
  • Galactose* / metabolism
  • Galactose* / pharmacology
  • Germ Cells / drug effects
  • Germ Cells / metabolism
  • Leydig Cells* / drug effects
  • Leydig Cells* / metabolism
  • Male
  • Mice
  • Organ Culture Techniques* / methods
  • Oxidative Stress / drug effects
  • Reactive Oxygen Species / metabolism
  • Sertoli Cells / drug effects
  • Sertoli Cells / metabolism
  • Testis* / drug effects
  • Testis* / growth & development
  • Testis* / metabolism

Substances

  • Galactose
  • Reactive Oxygen Species

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