SEA-AD is a multimodal cellular atlas and resource for Alzheimer's disease

Michael Hawrylycz; Eitan S Kaplan; Kyle J Travaglini; Mariano I Gabitto; Jeremy A Miller; Lydia Ng; Jennie L Close; Rebecca D Hodge; Brian Long; Tyler Mollenkopf; Shoaib Mufti; Nicole M Gatto; Eric B Larson; Paul K Crane; Thomas J Grabowski; C Dirk Keene; Ed S Lein

doi:10.1038/s43587-024-00719-8

SEA-AD is a multimodal cellular atlas and resource for Alzheimer's disease

Nat Aging. 2024 Oct;4(10):1331-1334. doi: 10.1038/s43587-024-00719-8.

Authors

Michael Hawrylycz¹, Eitan S Kaplan², Kyle J Travaglini², Mariano I Gabitto², Jeremy A Miller², Lydia Ng², Jennie L Close², Rebecca D Hodge², Brian Long², Tyler Mollenkopf², Shoaib Mufti², Nicole M Gatto³, Eric B Larson⁴, Paul K Crane⁴, Thomas J Grabowski^{5

6}, C Dirk Keene⁷, Ed S Lein⁸

Affiliations

¹ Allen Institute for Brain Science, Seattle, WA, USA. [email protected].
² Allen Institute for Brain Science, Seattle, WA, USA.
³ Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
⁴ Department of Medicine, University of Washington, Seattle, WA, USA.
⁵ Department of Radiology, University of Washington, Seattle, WA, USA.
⁶ Department of Neurology, University of Washington, Seattle, WA, USA.
⁷ Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
⁸ Allen Institute for Brain Science, Seattle, WA, USA. [email protected].

PMID: 39402332
PMCID: PMC11577961 (available on 2025-04-01)
DOI: 10.1038/s43587-024-00719-8

Abstract

The Seattle Alzheimer’s Disease Brain Cell Atlas (SEA-AD) is a multifaceted open data resource designed to identify cellular and molecular pathologies that underlie Alzheimer’s disease. Integrating neuropathology, single cell and spatial genomics, and longitudinal clinical metadata, SEA-AD is a unique resource for studying the pathogenesis of Alzheimer’s and related dementias.

Abstract

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