A qualitative dyad analysis of barriers and facilitators of antiretroviral therapy (ART) adherence among people who inject drugs (PWID) with HIV in Kazakhstan

AIDS Care. 2025 Jan;37(1):151-160. doi: 10.1080/09540121.2024.2414078. Epub 2024 Oct 15.

Abstract

People with HIV (PWH) who inject drugs (PWID) face many barriers to ART adherence. Kazakhstan has one of the fastest growing HIV epidemics in the world, primarily fueled by injection drug use, yet ART adherence among PWID is low. Social support can help address these barriers, but ART adherence among PWID is rarely examined within the relationship context. We conducted interviews with 20 PWID with HIV and 18 of their intimate partners and performed a qualitative dyad analysis to examine ART adherence factors. The results indicated many barriers and facilitators of ART adherence at the individual level (e.g., substance use), interpersonal level (e.g., social support) and structural level (e.g., stigma, transportation). Reported adherence barriers and facilitators had high congruence between dyad members; however, some notable differences were found between dyads. Compared to PWH, partners without HIV had a lack of awareness about the role of stigma in impeding ART adherence. Different manifestations of social support to facilitate ART adherence were noted between seroconcordant dyads (e.g., taking pills together, attending appointments together) and serodiscordant dyads (e.g., reminders to take pills, providing babysitting to enable attendance at doctor appointments). Future research and programs may benefit from integrating dyad approaches into ART adherence interventions.

Keywords: ART adherence; HIV; People who inject drugs; SDG 10: reduced inequalities; dyad.

MeSH terms

  • Adult
  • Anti-HIV Agents / therapeutic use
  • Assessment of Medication Adherence*
  • Female
  • HIV Infections* / drug therapy
  • HIV Infections* / psychology
  • Humans
  • Interviews as Topic
  • Kazakhstan / epidemiology
  • Male
  • Medication Adherence* / psychology
  • Middle Aged
  • Qualitative Research*
  • Sexual Partners / psychology
  • Social Stigma*
  • Social Support*
  • Substance Abuse, Intravenous* / complications
  • Substance Abuse, Intravenous* / epidemiology
  • Substance Abuse, Intravenous* / psychology

Substances

  • Anti-HIV Agents