Correlation between lncRNAs with human molecular chaperons in cancer immunopathogenesis and drug resistance

Int Immunopharmacol. 2024 Dec 25;143(Pt 1):113309. doi: 10.1016/j.intimp.2024.113309. Epub 2024 Oct 14.

Abstract

The development of cancer immunology heavily relies on the interaction between long non-coding RNAs (lncRNAs) and molecular chaperones. By participating in gene regulation, lncRNAs interact with molecular chaperones, which play a critical role in protein folding and stress responses, to influence oncogenic pathways. This interaction has an impact on both the immune cells within the tumor microenvironment and the tumor cells themselves. Understanding these mechanisms provides valuable insights into innovative approaches for diagnosis and treatment. Targeting the lncRNA-chaperone axis has the potential to strengthen anti-tumor immunity and enhance cancer treatment outcomes. Further research is necessary to uncover specific associations, identify biomarkers, and develop personalized therapies aimed at disrupting this axis, which could potentially revolutionize cancer diagnosis and treatment.

Keywords: Cancer; Chaperons; Drug resistance; Immunopathogenesis; lncRNA.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Resistance, Neoplasm* / genetics
  • Drug Resistance, Neoplasm* / immunology
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Molecular Chaperones* / genetics
  • Neoplasms* / drug therapy
  • Neoplasms* / genetics
  • Neoplasms* / immunology
  • RNA, Long Noncoding* / genetics
  • RNA, Long Noncoding* / immunology
  • RNA, Long Noncoding* / metabolism
  • Tumor Microenvironment / genetics
  • Tumor Microenvironment / immunology

Substances

  • RNA, Long Noncoding
  • Molecular Chaperones