Diagnosing AL and ATTR Amyloid Cardiomyopathy: A Multidisciplinary Approach

Fabian Aus dem Siepen; Timon Hansen

doi:10.3390/jcm13195873

Diagnosing AL and ATTR Amyloid Cardiomyopathy: A Multidisciplinary Approach

J Clin Med. 2024 Oct 1;13(19):5873. doi: 10.3390/jcm13195873.

Authors

Fabian Aus dem Siepen¹, Timon Hansen²

Affiliations

¹ Department of Cardiology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
² Onkologicum HOPA, 22767 Hamburg, Germany.

Abstract

Amyloidosis with cardiac involvement is a fatal disease leading to progressive heart failure. The most common forms of amyloidosis with cardiac involvement are light chain (AL) and transthyretin (ATTR) amyloidosis. To allow effective specific treatment for both forms, precise and early diagnosis is important. This review focuses on diagnostic approaches for AL and ATTR amyloidosis with cardiac involvement, including different strategies, the role of imaging and biomarkers and possible pitfalls.

Keywords: AL; ATTR; ATTR-CM; amyloidosis; cardiomyopathy.

Publication types

Review

Grants and funding

This research received no external funding.