The Influence of Adherence to a Mediterranean Diet on Decompensation in Patients with Chronic Heart Failure

Nutrients. 2024 Sep 27;16(19):3278. doi: 10.3390/nu16193278.

Abstract

Background: Chronic heart failure (CHF) is a major health problem, representing the main cause of hospitalization in people over 65 years of age. Several studies have associated the Mediterranean diet with a cardioprotective function, improving prognoses in patients with high cardiovascular risk. Our main objective is to determine whether higher adherence to the Mediterranean diet is associated with a lower severity of CHF, based on the number of decompensations and disease complications.

Methods: This study was a single-center retrospective cohort study conducted at the Virgen del Rocío Hospital (Seville). Adherence to a Mediterranean diet was determined by the Mediterranean Diet Adherence Screener (MEDAS) in patients with chronic heart failure in a state of clinical stability, the number of decompensations in the 12 months before inclusion, cardiac biomarkers (NT-proBNP and CA125), evaluation of dyspnea, and quality of life assessment according to NYHA and KCCQ scales and analytical profiles.

Results: Seventy-two patients were included (35 with high adherence to the Mediterranean diet and 37 with low adherence). The mean age was 81.29 ± 0.86 years. A trend towards fewer decompensations (1.49 ± 0.14 vs. 1.92 ± 0.17, p = 0.054) and lower NT-proBNP values (2897.02 ± 617.16 vs. 5227.96 ± 1047.12; p = 0.088) was observed in patients with high adherence compared to those with low adherence to the Mediterranean diet.

Conclusions: Our results suggest that patients with CHF and high adherence to the Mediterranean diet have a tendency towards an improved cardiac profile, indicated by fewer decompensations and lower NT-proBNP levels. Future clinical trials are needed to substantiate these hypotheses.

Keywords: Mediterranean diet; adherence; heart failure.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biomarkers / blood
  • Chronic Disease
  • Diet, Mediterranean*
  • Female
  • Heart Failure* / diet therapy
  • Humans
  • Male
  • Natriuretic Peptide, Brain / blood
  • Patient Compliance*
  • Peptide Fragments / blood
  • Quality of Life
  • Retrospective Studies

Substances

  • Natriuretic Peptide, Brain
  • pro-brain natriuretic peptide (1-76)
  • Biomarkers
  • Peptide Fragments

Grants and funding

This research received no external funding.