Aberration compensation in Doppler holography of the human eye fundus by subaperture signal correlation

Biomed Opt Express. 2024 Sep 4;15(10):5660-5673. doi: 10.1364/BOE.528568. eCollection 2024 Oct 1.

Abstract

The process of obtaining images of capillary vessels in the human eye's fundus using Doppler holography encounters difficulties due to ocular aberrations. To enhance the accuracy of these images, it is advantageous to apply an adaptive aberration correction technique. This study focuses on numerical Shack-Hartmann, which employs sub-pupil correlation as the wavefront sensing method. Application of this technique to Doppler holography encounters unique challenges due to the holographic detection properties. A detailed comparative analysis of the regularization technique against direct gradient integration in the estimation of aberrations is made. Two different reference images for the measurement of image shifts across subapertures are considered. The comparison reveals that direct gradient integration exhibits greater effectiveness in correcting asymmetrical aberrations.