Mouse models are an indispensable tool in lymphoma research. Here, we focus on the utilization of genetically engineered mouse models as preclinical avatars in lymphoma research. We describe lymphoma-relevant alleles and allele combinations, as well as general considerations for model selection. We further illustrate concepts of gene targeting and model design and provide guidelines for breeding strategies and colony maintenance.
Keywords: Allele design; Breeding strategies; Colony management; DLBCL in vivo models; Genetically engineered mouse models (GEMMs).
© 2025. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.