Deciphering the importance of nanostructures in advanced technologies for a broad application spectrum has far-reaching implications for humans and the environment. Cost-effective, abundant cobalt oxide nanoparticles (NPs) are among the most attractive and extensively utilized materials in biomedical sciences due to their high chemical stability, and biocompatibility. However, the methods used to develop the NPs are hazardous for human health and the environment. This article precisely examines diverse green synthesis methods employing plant extracts and microbial sources, shedding light on their mechanism, and eco-friendly attributes with more emphasis on biocompatible properties accompanied by their challenges and avenues for further research. An in-depth analysis of the synthesized cobalt oxide NPs by various characterization techniques reveals their multifaceted functionalities including cytotoxicity, larvicidal, antileishmanial, hemolytic, anticoagulating, thrombolytic, anticancer and drug sensing abilities. This revelatory and visionary article helps researchers to contribute to advancing sustainable practices in nanomaterial synthesis and illustrates the potential of biogenically derived cobalt oxide NPs in fostering green and efficient technologies for biomedical applications.
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