Leveraging trait and QTL covariates to improve genomic prediction of resistance to Fusarium head blight in Central European winter wheat

Front Plant Sci. 2024 Oct 4:15:1454473. doi: 10.3389/fpls.2024.1454473. eCollection 2024.

Abstract

Fusarium head blight (FHB) is a devastating disease of wheat, causing yield losses, reduced grain quality, and mycotoxin contamination. Breeding can mitigate the severity of FHB epidemics, especially with genomics-assisted methods. The mechanisms underlying resistance to FHB in wheat have been extensively studied, including phenological traits and genome-wide markers associated with FHB severity. Here, we aimed to improve genomic prediction for FHB resistance across breeding programs by incorporating FHB-correlated traits and FHB-associated loci as model covariates. We combined phenotypic data on FHB severity, anthesis date, and plant height with genome-wide marker data from five Central European winter wheat breeding programs for genome-wide association studies (GWAS) and genomic prediction. Within all populations, FHB was correlated with anthesis date and/or plant height, and a marker linked to the semi-dwarfing locus Rht-D1 was detected with GWAS for FHB. Including the Rht-D1 marker, anthesis date, and/or plant height as covariates in genomic prediction modeling improved prediction accuracy not only within populations but also in cross-population scenarios.

Keywords: Fusarium head blight; GBLUP; GWAS; Rht-D1; genomic prediction; trait covariates; wheat.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was conducted within the framework of the “WheatSustain” project (grant no. 771134), which was supported by the Horizon 2020 SusCrop ERA-NET Cofund Action, part of the Joint Programming Initiative on Agriculture, Food Security and Climate Change. Funding was provided by the Research Council of Norway (grant no. 299615), the German Federal Ministry of Education and Research (grant no. 031B0810), the Austrian Federal Ministry of Agriculture, Regions and Tourism (grant no. 101402), the Spanish Ministry of Education and Vocational Training’s Beatriz Galindo Program (grant no. BEAGAL18/00115), and the Spanish State Research Agency’s Severo Ochoa Program for Centres of Excellence in R&D (grant no. SEV-2016-0672).