Sulfoximine Aided Ru(II)-Catalyzed Asymmetric Double C(sp2)-H Hydroarylations of Olefins

Org Lett. 2024 Nov 1;26(43):9334-9339. doi: 10.1021/acs.orglett.4c03524. Epub 2024 Oct 21.

Abstract

Presented here is a sulfoximine-directed Ru(II)-catalyzed asymmetric intramolecular double C(sp2)-H hydroarylation of olefins. This process provides a diastereoselective and enantiospecific synthetic route to highly substituted tetrahydrobenzodifurans. Notably, the reaction accommodates labile functional groups and is scalable to gram quantities.